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国家自然科学二等奖:功能核酸分子识别及生物传感方法学研究

2020年09月29日

我校化学生物传感创新团队拥有谭蔚泓院士课题组历经多年努力,在功能核酸分子识别及生物传感方法学研究、纳米尺度和分子水平上生物信息获取的新原理与新方法、复杂体系成分分析及波谱结构解析的化学计量学研究等多个方面,获得了多项原创性成果和重要科学发现。“功能核酸分子识别及生物传感方法学研究”荣获国家自然科学二等奖。

“功能核酸分子识别及生物传感方法学研究”针对湿地污染修复国际国内研究热点和难点,开展了功能纳米材料和微生物 修复难降解有机物和重金属污染湿地新方法研究。重要科学发现如下:

1.发现负载羟基和羧基等官能团的磁性功能纳米材料对堆肥浸出液、污水处理厂 污泥尾水、湿地尾水、河湖底泥尾水、城市污水、工业废水和河湖水体中难降解有机 物和重金属污染的去除效果好,分离方便。基于这些发现,制备和合成了去除湿地及 相关水体中难降解有机物和重金属污染的系列高效低耗低成本的磁性功能纳米材料, 发现了这些材料的污染去除机理、规律和优化参数。

2.发现功能微生物结合纳米材料和生物材料可以有效降解堆肥浸出液、污水处理 厂污泥尾水、湿地尾水、河湖底泥尾水、城市污水、工业废水、河湖水体、堆肥、底 泥和湿地土壤中难降解有机物,钝化重金属。降解难降解有机物和钝化重金属的重要 途径是微生物或其多种代谢物与污染物发生吸附、离子交换、络合及纳米材料和有关 生物材料与污染物发生吸附。基于这些发现,发展了功能微生物结合纳米材料和有关 生物材料降解难降解有机物、钝化重金属的理论、技术和方法。

3.发现难降解有机物和重金属在一定条件下与毒莠定抗体、漆酶、葡萄糖氧化酶、 辣根过氧化酶等发生特异性识别的反应,会产生电流信号、电位信号、阻抗信号、荧 光信号等信号,并建立了这些难降解有机物和重金属的浓度与相关电流信号、电位信 号、阻抗信号和荧光信号的关系。基于这些发现,构建了检测堆肥浸出液、污水处理 厂污泥尾水、湿地尾水、河湖底泥尾水、城市污水、工业废水、河湖水体、堆肥、底泥和湿地土壤中难降解有机物和重金属污染的系列高效低耗低成本的纳米生物化学传感器。

成果包括:8篇代表性论文包括AngewChem(2)、JACS(3)被SCI他引642篇次,单篇最高他引192次;20篇主要论文被SCI他引1559篇次,获授权国家发明 专利13件。阶段性成果获省部级自然科学一等奖2项。培养国家杰青2人、教育部长江学者1人。项目完成人应邀担任NPGAsiaMater.ACSNano Nanoscale、AnalChem、Chem-AsianJ等国际期刊编委、国际国内重要学术 会议作特邀报告53次、并应邀为ChemRev.AccChemRes.AnnuRevAnal Chem等国际著名综述期刊撰写相关评述论文。

Prof. Weihong Tan earned his Ph.D. in Physical Chemistry at the University of Michigan in 1993 after he earned his M. Sc. in Physical Chemistry from Chinese Academy of Sciences and B. Sc. in Chemistry from Hunan Normal University. In addition to his current position as the Director of the State Key Laboratory of Chemo/Biosensing and Chemometrics and Distinguished Professor of Chemistry and Biology at Hunan University, he is also a University Distinguished Professor and a V.T. and Louis Jackson Professor at the University of Florida.Prof. Tan’s research is in the general area of Bioanalytical Chemistry and Chemical Biology. He specializes in bioanalysis, molecular engineering and DNA nanotechnology as well as biosensors. He has published over 500 peer-reviewed scientific papers. According to Thomson Reuters, he was among the small, prestigious group of Highly Cited Researchers in 2014, 2015 and 2016. The total citations of his publications exceed 30000 with an H index of 97 (SCI Web of Science). He served as the Associate Editor of Analytical Chemistry (USA) and Science Bulletin (China), and has served as either editorial or advisory board member for many journals, including the Journal of American Chemical Society, ACS Nano, and Chemical Sciences. He has received over thirty awards and honors, including the Academician of the Chinese Academy of Sciences in 2015, Second Class National Natural Science Award in China (2014), ACS Florida Achievement Award (2012), Elected Fellow of The American Association for the Advancement of Science (AAAS) (2005), Pittsburgh Conference Achievement Award for Analytical Chemistry and Applied Spectroscopy (2004) and Beckman Young Investigator Award (1997) etc.



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